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. 2014 Feb 15;9:e201402002. doi: 10.5936/csbj.201402002

Figure 3.

Figure 3

View of NCD25 docked to LSD1 catalytic core. (A) and (B) Views of the binding conformation of (1R,2S)-NCD25 (ball and stick). The yellow broken line indicates a hydrogen bond and the value indicates distance between the H atom of the amino group of cyclopropylamine and the O atom of the side chain of Tyr 761. (C) Schematic diagram of binding of (1R,2S)-NCD25. (D) and (E) Views of the binding conformation of (1S,2R)-NCD25 (ball and stick). The yellow broken line indicates a hydrogen bond and the value indicates distance between the H atom of the amino group of cyclopropylamine and the carbonyl oxygen of Ala 809. (F) Schematic diagram of binding of (1S,2R)-NCD25.