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. 2013 Oct 30;63(5):861–863. doi: 10.1136/gutjnl-2013-305736

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

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p62 amplifies steatosis, inflammation and fibrosis in murine methionine–choline-deficient (MCD)-induced non-alcoholic steatohepatitis. (A) Gene expression of Ccl2/Mcp1 normalised to 18S of wild-type (wt) or p62 transgenic (tg) livers on control (ctrl) or MCD diet. (B) Lipid accumulation after 2 weeks on MCD diet is visualised by Scharlach Red stain and hepatic collagen deposition after 4 weeks on MCD diet is visualised by polarisation microscopy after Sirius Red staining. (C) Relative hepatic mRNA expression of Srebp1c normalised to 18S. (D) Relative mRNA expression of Ctgf normalised to 18S. Data in A, C and D are represented as individual values and box plots with median (—) and mean (□) in a five-number summary (n=9–12).