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Clusters of JC virus progeny virions observed by electron microscopy. JC virus progeny virions were detected as clusters ranging from approximately 200 nm to more than 1 μm. The size of viral clusters correlated with the size of PML-NBs, suggesting that viral progeny production occurs in association with growing PML-NBs. Scale bars = (A) 1 μm; (B) 250 nm; (C) 50 nm.
