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(a) Virological and biochemical outcomes after long-term NA therapy. ▪: undetectable HBV DNA (<3.0 log copies/mL); ▪: normalization of ALT (<30 IU/L); □: HBe seroconversion of hepatitis B e antigen-positive patients. (b) Percentages of patients with serum HBsAg levels <2000 C.O.I. before/after long-term NA therapy. □: HBsAg <2000 C.O.I. before NA treatment; ▪: HBsAg <2000 C.O.I. after NA treatment.
