Table 3.

Characteristics of patients with HCC and without HCC after long-term NA therapy

	Without HCC (n = 158)	With HCC (n = 9)	p value
Before NA treatment
Age (years)	48.9	54.8	0.115
Gender (male/female)	104/54	9/0	0.033
Chronic hepatitis/liver cirrhosis	122/36	4/5	0.040
HBV DNA (log copies/ml)	6.7	7.1	0.840
HBV genotype C (%)	96	88	0.358
HBeAg positive (%)	22	52	0.180
ALT (IU/L)	142	72	0.675
Previous IFN treatment (%)	26	33	0.627
Maternal transmission (%)	50	71	0.306
Period of NA treatment (years)	5.7	6.8	0.213
At HCC
HBV DNA < 2.1 log copies/ml (%)	69	78	0.552
HBsAg < 2000 C.O.I. (%)	16	11	0.652
ALT < 40 (IU/L)	91	100	0.500