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. 2014 Mar 19;14:206. doi: 10.1186/1471-2407-14-206

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Copyright © 2014 Hutzen et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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MV-hE:A and MV-mE:A conditioned media inhibit angiogenic processes. (A) Conditioned media (10 μg/ml total protein) from the MV-E:A viruses, but not MV-GFP inhibits tube formation in bEnd.3 mouse endothelial cells stimulated with 20 ng/ml recombinant mouse VEGF (*p ≤ 0.05, ** p ≤ 0.001). (B) MV-E:A conditioned media suppresses VEGF enhancement of cell viability in HUVEC and bEnd.3 cells (*p ≤ 0.05). (C) An angiogenesis protein array reveals that MV-hE:A conditioned media (100 μg/ml total protein) downregulates multiple angiogenic proteins in HUVECs compared to MV-GFP. Changes in protein expression are quantified in the accompanying bar graph.