Fig. 3.

ATGL overexpression increases serum BHBA regardless of genotype. WT or L-FABP KO mice, at 8–10 weeks of age, were transduced with control (cont) or ATGL shRNA adenovirus (n = 8–10 per group) (A–C) or Ad-GFP or Ad-ATGL adenovirus (n = 8–10 per group) (D–F). Mice were fed with purified control diet and euthanized 7 days postinfection. Serum TG (A, D), BHBA (B, E), and NEFA (C, F) were measured with a colorimetric enzymatic kit after an overnight (A–C) or 4 h fast (D–F). Data are presented as mean ± SEM. *P < 0.05 versus GFP; ^#P < 0.05 versus WT mice.