Fig. 6.

Impact of hepatocyte-specific MTP deficiency (L-Mttp^−/−) on macrophage-to-feces RCT. An in vivo macrophage-to-feces RCT experiment was performed in L-Mttp^−/− mice as detailed in Materials and Methods. A: Cholesterol tracer appearance in plasma 6, 24, and 48 h after macrophage administration. B: Cholesterol tracer recovery within liver 48 h after macrophage injection. C: Cholesterol tracer appearance in feces collected continuously from 0 to 48 h after macrophage injection. Data are presented as means ± SEM, at least n = 6 for each group. Statistically significant differences from the control group are indicated as *P < 0.05.