TABLE 2.
Fecal excretion of neutral sterol and bile acid species in vehicle- and MTP inhibitor-treated wild-type mice
| Vehicle | MTP Inhibitor | |
| Fecal output (g/24 h) | 0.85 ± 0.07 | 0.87 ± 0.07 |
| Neutral sterol species in feces | ||
| Cholesterol (nmol/24 h) | 3,799.20 ± 213.87 | 6,318.96 ± 469.60b |
| Dihydrocholesterol (nmol/24 h) | 385.76 ± 12.66 | 417.26 ± 17.62 |
| Coprostanol (nmol/24 h) | 930.97 ± 95.82 | 2,208.34 ± 490.14a |
| Bile acid species in feces | ||
| Allocholic acid (nmol/24 h) | 68.64 ± 7.02 | 59.97 ± 4.49 |
| α-Muricholic acid (nmol/24 h) | 153.77 ± 12.85 | 97.95 ±3.26b |
| β-Muricholic acid (nmol/24 h) | 206.10 ± 17.19 | 190.64 ± 7.24 |
| ω-Muricholic acid (nmol/24 h) | 894.72 ± 67.29 | 713.17 ± 42.57a |
| Cholic acid (nmol/24 h) | 199.34 ± 18.54 | 169.75 ± 16.01 |
| Deoxycholic acid (nmol/24 h) | 1,154.51 ± 90.40 | 934.82 ± 40.57a |
| Hyodeoxycholic acid (nmol/24 h) | 107.31 ± 7.81 | 74.76 ± 7.71a |
Feces were collected over a 24 h period. Data are presented as means ± SEM, at least n = 6 for each group.
a
P < 0.05 versus control mice.
b
P < 0.001 versus control mice.