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Proposed mechanism of Angptl4 transcription. A: When glucocorticoids are present without insulin, FoxO1 binds to the Angptl4 FRE and helps GR transcribe Angptl4. B: When both glucocorticoid and insulin are present, Akt inactivates FoxO1 by phosphorylation, which results in the export of FoxO1 from the nucleus. Without FoxO1 protein, glucocorticoid-induced Angptl4 gene expression is greatly reduced.
