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Correlation of genotype and phenotype. For each species, the in vitro IC50 (in µM) of the drugs simvastatin (A) and terbinafine (B) is plotted versus the highest score attained of the species’ proteome against the HMM profile of the presumed target of that drug. Gla, G. lamblia; L6, rat L6 myoblasts; Ldo, L. donovani; Pfa, P. falciparum; Tbr, T. brucei; Tcr, T. cruzi.
