TABLE 4.
Median concentrations of individual bile acids obtained by the HPLC method without alkaline hydrolysis (method A)
| Control (n = 10) (μmol/g) | Early (n = 17) (μmol/g) | Advanced (n = 23) (μmol/g) | |
| Totala | 6.69 | 3.98 | 1.30 |
| Subtotalb | 6.61 | 3.81 | 1.14 |
| CA (1) | 0.00 | 0.00 | 0.24 |
| CDCA (2) | 0.00 | 0.12 | 0.15 |
| DCA (3) | 3.84 | 0.89 | 0.08 |
| LCA (4) | 1.46 | 0.78 | 0.00 |
| UDCA (5) | 0.01 | 0.08 | 0.00 |
| isoDCA (8) | 0.41 | 0.12 | 0.00 |
| isoLCA (9) | 0.22 | 0.09 | 0.00 |
| HCA (11) | 0.00 | 0.00 | 0.00 |
| HDCA (13) | 0.26 | 0.00 | 0.00 |
| isoLCA-Δ5 (24) | 0.00 | 0.00 | 0.00 |
| 7ketoLCA (33) | 0.00 | 0.00 | 0.00 |
| 7ketoDCA (34) | 0.00 | 0.00 | 0.00 |
| LCA-3-one (35) | 0.11 | 0.05 | 0.00 |
a
Sum of all the bile acid species examined by this method.
b
Sum of CA, CDCA, DCA, LCA, isoDCA, isoLCA, UDCA, and HCA which are common bile acid species examined by three different methods. Abbreviations of bile acids and their compound numbers in parentheses are given in the Appendix.