Table 2.

Malignancy risk based upon type of gonadal dysgenesis, location of gonad, gross pathology, and immunohistochemistry

	Low risk	Intermediate risk	High risk
Degree of virilization	Normally virilized males	Mild undervirilization	Ambiguous genitalia
Location of gonad	Scrotal gonad with normal appearance	Inguinal gonad	Abdominal gonad
Gross pathology	-Streak gonad without germ cells	Dysgenetic testicle that is OCT 3/4 positive with intermediate risk criteria	-Undifferentiated gonadal tissue
	-Ovary
	- Testicle (OCT 3/4 negative)
	- Dysgenetic testicle that is OCT 3/4 negative		-Dysgenetic testicle that is OCT 3/4 positive with high risk criteria
Immunohistochemistry	OCT 3/4 negative	OCT 3/4 positive cells located luminally, scattered within the whole gonad, TSPY negative or weakly positive, SCF negative, age < 1 year.	OCT 3/4 positive cells located in the basal lamina, focal location, TSPY strongly positive, SCF positive, age > 1 year.

Adapted from Pleskacova, et al. [45].