Table 2.

Transcripts Downregulated in Pitx2^{Δflox/Δflox} EOM Compared with Pitx2^flox/flox EOM Common to 3-week, 6-week, and 3-month Time Points

Accession No.	Gene Symbol	Gene Title	Go Biological Process Term	3w Fold Change	6w Fold Change	3m fold Change
NM_009393	Tnnc1	troponin C, cardiac/slow skeletal	regulation of muscle contraction /// regulation of muscle filament sliding speed /// regulation of ATPase activity	−3.7	−8.8	−12
NM_011619	Tnnt2	troponin T2, cardiac	regulation of muscle contraction /// muscle filament sliding /// regulation of ATPase activity	−4.1	−19	−11
L47552	Tnnt2	troponin T2, cardiac	regulation of muscle contraction /// muscle filament sliding /// regulation of ATPase activity	−3.9	−16	−8.8
BE952392	Myh7b	myosin, heavy chain 7B, cardiac muscle, beta	---	−2.9	−4.1	−3.4
NM_010861	Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	cardiac myofibril assembly /// ventricular cardiac muscle tissue morphogenesis /// heart contraction	−4.3	−7.9	−7.1
NM_080728	Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	muscle contraction /// muscle filament sliding /// ventricular cardiac muscle tissue morphogenesis	−3.1	−6.5	−10
M76601	Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	regulation of the force of heart contraction ///muscle contraction /// striated muscle contraction /// regulation of heart contraction	−6.4	−14	−6.3
BB481540	Myh6 /// Myh7	myosin, heavy polypeptide 6, cardiac muscle, alpha /// myosin, heavy polypeptide 7, cardiac muscle, beta	regulation of the force of heart contraction /// striated muscle contraction	−3.4	−20	−7.0
NM_021467	Tnni1	troponin I, skeletal, slow 1	regulation of muscle contraction /// ventricular cardiac muscle tissue morphogenesis	−5.6	−18	−24
BB772205	Enho	energy homeostasis associated	---	−2.6	−4.1	−5.2
BB772205	Enho	energy homeostasis associated	---	−2.3	−4.5	−5.7
AK005148	Cyfip2	cytoplasmic FMR1 interacting protein 2	apoptosis /// apoptosis /// cell adhesion /// cell-cell adhesion /// cell-cell adhesion	−2.0	−2.6	−2.4
BB333374	Zfp385b	zinc finger protein 385B	---	−2.7	−5.1	−6.2
BE982894	Zfp385b	zinc finger protein 385B	---	−2.8	−4.5	−5.0
AK002622	Pln	phospholamban	regulation of the force of heart contraction /// calcium ion transport /// regulation of calcium ion transport	−3.0	−4.8	−3.3
AI426503	Mfsd4	major facilitator superfamily domain containing 4	transport /// transmembrane transport	−2.3	−3.5	−2.6
BB278653	Cacna2d4	calcium channel, voltage-dependent, alpha 2/delta subunit 4	transport /// ion transport /// calcium ion transport /// visual perception /// response to stimulus	−4.3	−17	−12
AK002622	Pln	phospholamban	regulation of the force of heart contraction /// calcium ion transport /// regulation of calcium ion transport	−2.2	−3.3	−2.2
AK002622	Pln	phospholamban	regulation of the force of heart contraction /// calcium ion transport /// regulation of calcium ion transport	−3.0	−5.3	−3.2
BC010288	Psp	parotid secretory protein	---	−6.4	−18	−62
NM_007389	Chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	ion transport /// neuromuscular synaptic transmission /// regulation of membrane potential	−2.2	−3.2	−3.4
BB020678	Fam196b	family with sequence similarity 196, member B	---	−2.9	−7.0	−16
AV026232	4832428D23Rik	RIKEN cDNA 4832428D23 gene	---	−2.1	−2.1	−4.1