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. 2014 Mar 13;9:74. doi: 10.1186/1748-717X-9-74

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Copyright © 2014 Castillo et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Lung segmentation and removal of PET spill-over activity artifacts. Semi-automated histogram segmentation and morphological region growing were used to delineate the set of lung voxels on the pre-treatment staging PET/CT studies. PET spill-over activities into the lung ROI were manually contoured for exclusion. Top row: lung ROI shown (a) before and (b) after manual correction of cardiac spill-over activity. Bottom row: the region of exclusion due to tumor is show in red (c) before and (d) after manual correction.