Table 3.
Logistic regression analysis for grade ≥ 2 RP
| Predictor | Coefficient | SE | Odds ratio (95% CI) | p-value |
|---|---|---|---|---|
| SUVmax |
0.16 |
0.095 |
1.2 (0.97, 1.4) |
0.10 |
| SUVmean |
0.34 |
0.15 |
1.4 (1.1, 1.9) |
<0.02
a,b
|
| SUVSD1 |
1.5 |
0.54 |
4.4 (1.5, 12.8) |
<0.0057
a,b
|
| SUV801 |
0.31 |
0.13 |
1.4 (1.1, 1.7) |
<0.013
a,b
|
| SUV901 |
0.33 |
0.12 |
1.4 (1.1, 1.7) |
<0.0061
a,b
|
| SUV951 |
0.33 |
0.12 |
1.4 (1.1, 1.7) |
<0.0049
a,b
|
| HUmax2 |
0.013 |
0.02 |
1 (0.97, 1.1) |
0.51 |
| HUmean2 |
-0.09 |
0.34 |
0.91 (0.47, 1.8) |
0.79 |
| HUsd2 |
-0.18 |
0.93 |
0.83 (0.14, 5.1) |
0.85 |
| HU802 |
-0.07 |
0.37 |
0.93 (0.46, 1.9) |
0.85 |
| HU902 |
-0.10 |
0.32 |
0.91 (0.48, 1.7) |
0.76 |
| HU952 |
-0.10 |
0.32 |
0.91 (0.48, 1.7) |
0.76 |
| MLD3 |
0.88 |
0.58 |
2.4 (0.78, 7.5) |
0.13 |
| V53 |
0.15 |
0.53 |
1.2 (0.41, 3.3) |
0.77 |
| V103 |
0.58 |
0.55 |
1.8 (0.6, 5.3) |
0.30 |
| V203 |
1.1 |
0.63 |
3 (0.87, 10.5) |
0.081 |
| V303 |
1.2 |
0.57 |
3.3 (1.1, 10.3) |
0.035 |
| FEV1(%)2 |
-0.13 |
1 |
0.88 (0.12, 6.6) |
0.897 |
| DLCO(%)2 | -1.2 | 1.1 | 0.31 (0.034, 2.9) | 0.31 |
1Scaled by 10.
2Scaled by 0.01.
3Log-transformation applied to improve model fit.
aSequentially rejective Bonferroni method applied to adjust for multiplicity at the α = 0.05 familywise significance level.
bOdds of grade ≥ 2 radiation pneumonitis increased with SUVmean, SUVSD, SUV80, SUV90, and SUV95.
Note: SE = standard error of the estimated coefficient parameter; CI = confidence interval for the odds ratio; p-values derived from two-sided hypothesis tests using Wald chi-square.