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. 2014 Mar 13;21(1):21. doi: 10.1186/1423-0127-21-21

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Copyright © 2014 Cheng et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The HPSE inhibitor OGT2115 did not affect osteogenic differentiation of mouse BM-MSCs. (A) The expression levels of Hpse1 increased during osteogenic differentiation. (B) Osteogenic potential was characterized by ARS staining after 21 days induction at the fourth passage of BM-MSCs with or without OGT2115. Quantifications of ARS staining of OGT2115 and control groups showed no difference (n = 3). (C) Quantitative real-time PCR analysis on the mRNA expression levels of Mmp2, Mmp9 and Mmp14 with or without the treatment of OGT2115 detected a significantly increased Mmp9 expression when HPSE1 is enzymatically inhibited. Error bars represent standard deviation.