Table 2.

Patient criteria for genetic testing according to NCCN clinical practice guidelines in oncology v.1.2010 [21]for HBOC

Patient 1	Patient 2	Criteria
	X	Personal history of breast cancer ≤ 45 years
		Personal history of two primary breast cancers, the first being diagnosed before 50 years of age
		Personal history of breast cancer with age at diagnosis < 50 years with limited family history
	X	Personal history of breast cancer ≤ 50 years with ≥ 1 relative with breast cancer ≤ 50 years and/or ≥ 1 relative with epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer at any age
		Personal history of triple-negative breast cancer, with age at diagnosis < 60 years
X		Personal history of breast cancer at any age, with ≥ 2 relatives with breast cancer and/or epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer at any age
		Personal history of breast cancer + Personal history of epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer