Figure 1. HK-2 viability inhibited by IS and restored by DPP-4 inhibitor.

(A) Dose-dependent effect of IS on HK-2 cells viability. HK-2 cells were incubated with various concentration of IS for 3 days. (B) Dose-dependent effect of DPP-4 inhibitor on IS-treated HK-2 cells. HK-2 cells were incubated with 1 mM of IS for 3 days followed by treatment with various concentrations of DPP-4 inhibitor. Cell viability was determined by MTT assay, and data are presented as percentage of viability.