Figure 3. DPP-4 inhibitor reversed the changes in levels of p-AKT, AKT (A) and caspase-3 (B) induced by 1 mM IS.

Cells were exposed to 1 mM IS for 3 h and then treated with 100 ng/mL DPP-4 inhibitor. The treated cells were lysed for determination of p-AKT, AKT and Caspase-3 by immunoblot using specific antibodies and chemiluminescence development.