Figure 5. Representative structure similarity network for the cytGST superfamily.

131 representative structures for 379 cytGST structures filtered to 95% sequence identity are shown. Edges are shown as for Figure 1 except that structural similarity is defined from the FAST algorithm, with a FAST SN score ≥20 required to show edges. 565 edges are shown. For this network the median SN score is 22.7 over 187 residues. (A) Nodes are colored by level 2 subgroup assignments. (B) Nodes are colored by reaction type. As with the level 2 sequence similarity network, multiple reaction types are broadly spread throughout the structure similarity network, indicating that some divergent structures catalyze the same reaction types. Reaction type abbreviations: multiple, multiple reaction types present; DSBR, disulfide bond reductase; NAS, nucleophilic aromatic substitution; NS, nucleophilic substitution; RD, reductive dehalogenase.