Table 1. Human JAK-STAT components predicted to be targets of broadly conserved miRNAs.
Target | 3′ UTR length | miRNAs | Publication |
JAK1 | 1.3 kb | miR-17/20/93/106 | |
JAK2 | 1.4 kb | miR-135a | Wu et al.80 |
JAK3 | 2.0 kb | ||
TYK2 | 0.3 kb | ||
STAT1 | 1.7 kb | miR-145,a miR-221/222a | Gregerson et al.,81 Lu et al.82 |
STAT2 | 1.8 kb | ||
STAT3 | 2.5 kb | let-7,a miR-17/20/93/106, miR-124, miR-125/351 | Koukos et al.,83 Wang et al.,84 |
STAT4 | 0.3 kb | ||
STAT5A | 1.3 kb | ||
STAT5B | 2.5 kb | miR-23 | |
STAT6 | 1.2 kb | miR-135 | |
SOCS1 | 0.4 kb | miR-19, miR-30/384 | |
SOCS2 | 1.0 kb | ||
SOCS3 | 1.6 kb | miR-19, miR-30/384, miR-148/152, miR-218 | |
SOCS4 | 5.1 kb | let-7/98, miR-9a | Zhuang et al.85 |
SOCS5 | 2.6 kb | miR-124 | |
SOCS6 | 3.9 kb | miR-15/16/195/322, miR-17/20/93/106, miR-25/32/92/363/367, miR-27, miR-30/384, miR-128, miR-130/301, miR-137, miR-142 | |
SOCS7 | 6.1 kb | let-7/98, miR-17/20/93/106, miR-26, miR-29, miR-96, miR-218 | |
PIAS1 | 0.2 kb | ||
PIAS2 | 0.3 kb | ||
PIAS3 | 0.9 kb | miR-9, miR-18,amiR-21a | Wu et al.,86 Xiong et al.34 |
PIAS4 | 0.2 kb | miR-29 |
Sites with higher probability of preferential conservation are reported from TargetScan Release 6.2 (published interactions shown in bold).25 Due to space constraints only miR-1 up to miR-400 are included, and sites with lower probability of conservation are not shown. aHuman miRNA-target relationships reported in the literature but not predicted by TargetScan to have higher probability of preferential conservation (also shown in bold). For brevity, published mouse miRNA-target relationships are not listed.