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. Author manuscript; available in PMC: 2014 Jun 21.
Published in final edited form as: Connect Tissue Res. 2013 Jun 21;54(0):245–251. doi: 10.3109/03008207.2013.800867

Figure 1.

Figure 1

Model of the three classes of 3Hyp substrate sites identified in A-clade collagen. 3Hyp always occurs in the sequence Gly-3Hyp-4Hyp, A. We propose the Class 1 3Hyp (Pro986) functions in collagen fibril molecular packing, in which the subunits are in-register dimers staggered axially by D-periods, B. D-periodic spacing is evident between the Class 2 3Hyp residues (Pro470, Pro707 and Pro944) in the triple helix, C. Occurrence of the Class 3 3Hyp residues in the (GPP)n motif exhibited clear tissue specificity, with the modification occurring almost exclusively in tendon.