Table 4. Gene ontology terms correlated to demyelination as revealed by Gene Set Enrichment Analysis.
| Gene ontology terms(biological process) | Size(N) | Gene symbols | Normalizedenrichmentscore | p-value |
| Gene ontology terms positively correlated with Luxol fast blue -negative white matter area (myelin-loss) | ||||
| Viral reproduction | 5 | CALCOCO2, CD81, TOP2A, CCL2, HBXIP | 1.71 | 0.0099 |
| Viral infectious cycle | 4 | CD81, TOP2A, CCL2, HBXIP | 1.65 | 0.0224 |
| Viral reproductive process | 4 | CD81, TOP2A, CCL2, HBXIP | 1.65 | 0.0224 |
| Mitotic cell cycle | 9 | TPX2, KIF23, CDKN1A, BTG3, SMC4, NEK6, CDKN2C, AFAP1L2, CDK2AP1 | 1.62 | 0.0358 |
| Humoral immune response | 4 | BLNK, PSMB10, CCL2, LY86 | 1.58 | 0.0106 |
| Regulation of protein metabolic process | 7 | TIMP1, IRAK3, CD81, TLR3, DNAJC1, CCND2, TLR1 | 1.43 | 0.0395 |
| Gene ontology terms negatively correlated with Luxol fast blue -negative white matter area (myelin-loss) | ||||
| Generation of precursor metabolites and energy | 5 | DDO, PPOX, GSK3B, ALDH5A1, COX17 | −1.30 | 0.0396 |
CDKN2C = cyclin-dependent kinase inhibitor 2C; AFAP1L2 = actin filament associated protein 1-like 2; ALDH5A1 = aldehyde dehydrogenase 5 family, member A1; BLNK = B-cell linker; BTG3 = BTG family, member 3; CALCOCO2 = calcium binding and coiled-coil domain 2; CCL2 = chemokine (C-C motif) ligand 2; CCND2 = cyclin D2; CD81 = CD81 molecule; CDK2AP1 = CDK2-associated protein 1; CDKN1A = cyclin-dependent kinase inhibitor 1A; COX17 = cytochrome c oxidase, subunit XVII assembly protein homolog; DDO = D-aspartate oxidase; DNAJC1 = DnaJ (Hsp40) homolog, subfamily C, member 1; GSK3B = glycogen synthase kinase 3 beta; HBXIP = hepatitis B virus x interacting protein; IRAK3 = interleukin-1 receptor-associated kinase 3; KIF23 = kinesin family member 23; LY86 = lymphocyte antigen 86; NEK6 = NIMA (never in mitosis gene a)-related kinase 6; PPOX = protoporphyrinogen oxidase; PSMB10 = proteasome (prosome, macropain) subunit, beta type, 10; SMC4 = structural maintenance of chromosomes 4; TIMP1 = tissue inhibitor of metalloproteinase 1; TLR1 = toll-like receptor 1; TLR3 = toll-like receptor 3; TOP2A = topoisomerase (DNA) II alpha 170 kDa; TPX2 = TPX2, microtubule-associated, homolog.