Table 1.
Cohort 1 | Cohort 2 | |||
---|---|---|---|---|
Controls* | T1D** | Controls* | T1D** | |
Number of subjects | 31 | 27 | 11 | 11 |
Age at blood draw (median, range) | 25, 8–44 | 18, 9–39 | 26, 16–33 | 15, 10–23 |
Gender M/F | 10/21 | 16/11 | 4/7 | 6/5 |
Antibody Positive (IAA, GAD65, IA- 2, ZNT8) | 1***/28 | 24/27 | 0/11 | 11/11 |
HLA DQ8 | 26/30 | 24/27 | 2/11 | 4/11 |
HLA DR3/DR4 | 3/30 | 10/27 | 1/11 | 1/11 |
Controls are either 1st degree relatives with no antibodies or HLA matched general population cohort of DAISY/TEDDY
T1D are recent onset patients within 6 months of diagnosis who were typed for HLA-DQ8
Antibody-positive control was not removed from the dataset; p-values did not differ significantly when data were analyzed with and without this value.