Table 2.
Cohort 1 - T cell Responses to defined autoantigens and WE14 TGase treated and untreated
| ANTIGEN | T1D Mean SI | +/− | Control Mean SI | +/− | P-Value* |
|---|---|---|---|---|---|
| Tetanus Toxoid | 58.1 | 73.9 | 61.9 | 81.1 | 0.895 |
| Pediacel® | 123.4 | 95.8 | 145.2 | 132.1 | 0.452 |
| P 1 | 2.5 | 3.1 | 0.9 | 0.8 | 0.079 |
| B 9-23 | 2.4 | 2.7 | 1.1 | 1.5 | 0.047 |
| GAD 3 | 2.5 | 3.7 | 1.7 | 1.7 | 0.441 |
| GAD 4 | 3.1 | 3.9 | 1.8 | 2.1 | 0.148 |
| R 2 (IA-2) | 2.0 | 2.4 | 2.2 | 2.7 | 0.873 |
| WE14, 20 μM | 2.5 | 2.3 | 1.5 | 1.5 | 0.086 |
| WE14, 40 μM | 2.6 | 2.7 | 1.5 | 1.4 | 0.042 |
| WE14 + TGase, 20 μM** | 2.8 | 3 | 1.3 | 1.3 | 0.005 |
| WE14 + TGase, 40 μM** | 3.5 | 4.2 | 1.8 | 1.4 | 0.040 |
| TGase only | 1.3 | 1.4 | 1.4 | 1.7 | 0.680 |
*
SI was computed as total spot numbers per analyte/total spot numbers for no antigen. Results were compared using Student’s T test. Values which were significant are in bold type. Spot numbers for no antigen for type 1 patients was 2.5 +/− 2.0 and for control subjects 2.7 +/− 3.4.
**
Due to the TGase-treatment protocol used for cohort 1, the concentrations shown represent theoretical maximal concentrations. Actual concentrations may be significantly lower.