Table 3. Etiology-based comparison of microbiota: NASH.
Etiologies other than NASH (n=181) | NASH cirrhosis (n=32) | |
---|---|---|
Age | 56.6±6.6 | 59.5±4.7* |
BMI | 28.6±5.8 | 35.3±4.7* |
MELD score | 12.7±5.9 | 12.0±7.3 |
Prior overt HE on treatment (%) | 40% | 34% |
Endotoxin (EU/ml) | 0.65±0.86 | 0.76±0.97 |
Microbiota (Phylum_Taxon) | ||
Bacteroidetes Bacteroidaceae | 19.3 | 42.7* |
Bacteroidetes Porphyromonadaceae | 1.4 | 3.9* |
Firmicutes Veillonellaceae | 1.9 | 0.0* |
Cirrhosis Dysbiosis Ratio | 0.80 | 0.63 |
p<0.05, we found a higher abundance of Porphyromonadaceae, Bacterioidaceae and lower Veillonellaceae in NASH patients who were also older and had a higher BMI than the non-NASH counterparts. No change in other bacteria from phylum Firmicutes was seen. Only bacterial taxa with an abundance >1% in either comparison are shown; rest were nonsignificant.