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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Immunol. 2014 Mar 21;192(9):4263–4272. doi: 10.4049/jimmunol.1303185

FIGURE 1.

FIGURE 1

Enhanced inflammatory response in hip1 mutant-infected DCs. (A) Purified BMDCs derived from C57BL/6J mice were exposed to medium alone (ui) or infected with the wild type (wt), hip1 mutant or hip1 mutant complemented with Hip1 (comp) Mtb at MOI=5. 24 hours post-infection, cell free supernatants were assayed for IL-12p40 and IL-12p70 by ELISA. Purified C57BL/6J BMDCs were infected with heat-killed wild type (wt), hip1 mutant or comp strain at MOI=5. 24 hours post-infection, cell free supernatants were assayed for IL-12p40, IL-12p70 (B) and IL-23, IL-6, TNF-α, IL-1β and IL-18 (C) by ELISA. Data are representative of three independent experiments. Values are presented as mean +/− SD. *, p <0.05; **, p<0.01; ***, p<0.001.