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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Immunol. 2014 Mar 21;192(9):4263–4272. doi: 10.4049/jimmunol.1303185

FIGURE 7.

FIGURE 7

Mtb interacts with human DCs to impair T cell differentiation. (A) Human MDCs were infected with heat-killed wild type (wt) or hip1 mutant Mtb at MOI=10 for 24 hours. Cell free supernatants were assayed for IL-12p40 and IL-6 by ELISA (B) MDCs infected with heat-killed wild type (wt) or hip1 mutant were co-cultured with autologous lymphocytes isolated from the corresponding donors for 3 days. Cell free supernatants were assayed for IFN-γ and IL-17 by ELISA. Data from 3 healthy donors are represented. Values are presented as mean +/−SD. *, p <0.05; **, p<0.01; ***, p<0.001.