Integrated regulation of hepatic taurocholate metabolism and cysteine sulfinic acid decarboxylase (CSAD) mRNA expression by farnesoid X receptor (FXR) and small heterodimer partner (SHP) (green = promotion or stimulation, red = inhibition). CDO, cysteine dioxygenase; CYP7A1, cholesterol 7-α-hydroxylase; CYP8B1, sterol 12-α-hydroxylase; FGF, fibroblast growth factor; LXR, liver X receptor.