Table 3.
Non-hematologic adverse events (AEs) and hematologic laboratory abnormalities (N = 60)
| AE or laboratory abnormality |
n (%) |
|||
|---|---|---|---|---|
| Grade 1/2 | Grade 3 | Grade 4 | Any grade | |
| Non-hematologic AEs of any cause occurring in ≥ 15% of patients | ||||
| Fatigue/asthenia |
33 (55) |
12 (20) |
0 |
45 (75) |
| Diarrhea |
33 (55) |
3 (5) |
0 |
36 (60) |
| Stomatitis, oral discomfort, and related oral syndromes |
29 (48) |
3 (5) |
0 |
32 (53) |
| Dysgeusia |
27 (45) |
0 |
0 |
27 (45) |
| Hypertension |
18 (30) |
8 (13) |
0 |
26 (43) |
| Skin and subcutaneous tissue disorders |
25 (42) |
0 |
0 |
25 (42) |
| Vomiting |
19 (32) |
2 (3) |
0 |
21 (35) |
| Dyspepsia |
20 (33) |
0 |
0 |
20 (33) |
| Epistaxis |
18 (30) |
2 (3) |
0 |
20 (33) |
| Nausea |
20 (33) |
0 |
0 |
20 (33) |
| Headache |
17 (28) |
2 (3) |
0 |
19 (32) |
| Decreased appetite |
14 (23) |
4 (7) |
0 |
18 (30) |
| Dry skin |
14 (23) |
1 (2) |
0 |
15 (25) |
| Ejection fraction decreased |
10 (17) |
3 (5) |
1 (2) |
14 (23) |
| Abdominal pain |
11 (18) |
0 |
0 |
11 (18) |
| Hand–foot syndrome and related disorders |
8 (13) |
3 (5) |
0 |
11 (18) |
| Pyrexia |
11 (18) |
0 |
0 |
11 (18) |
| Weight decreased |
11 (18) |
0 |
0 |
11 (18) |
| Constipation |
10 (17) |
0 |
0 |
10 (17) |
| Left ventricular dysfunction |
8 (13) |
2 (3) |
0 |
10 (17) |
| Insomnia |
8 (13) |
1 (2) |
0 |
9 (15) |
| Dyspnea |
8 (13) |
1 (2) |
0 |
9 (15) |
| Hematologic laboratory abnormalities | ||||
| Leukopenia |
46 (77) |
4 (7) |
1 (2) |
51 (85) |
| Anemia |
46 (77) |
2 (3) |
0 |
48 (80) |
| Neutropenia |
36 (60) |
9 (15) |
1 (2) |
46 (77) |
| Lymphopenia |
36 (60) |
6 (10) |
1 (2) |
43 (72) |
| Thrombocytopenia | 34 (57) | 6 (10) | 3 (5) | 43 (72) |