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. 2014 Apr 22;9(4):e95828. doi: 10.1371/journal.pone.0095828

Table 2. Multivariate analysis of the factors associated to the diagnosis of pulmonary TB, and the scoring for each variable, in HIV-infected adults and suspected smear-negative pulmonary TB, in Pernambuco, Brazil, 2007–2010.

Variables OR (95%-CI) p-value β New score* % PDA%***
Model 68.2
 Clinical Symptoms 88.4
Cough**
 No 1.0 0 points
 Yes 3.96 (1.95–8.05) 0.000 1.38 14 points 66.0
Weight loss
 No 1.0 0 points
 Yes 2.44 (1.43–4.15) 0.001 0.89 9 points 43.9
Fever
 No 1.0 0 points
 Yes 1.99 (1.22–3.23) 0.005 0.69 7 points 25.3
Malnutrition
 No 1.0 0 points
 Yes 2.62 (1.51–4.54) 0.001 0.96 10 points 18.6
Related to diagnostic methods for TB 62.0
Radiological pattern
 Normal 1.0 0 points
 Typical/Atypical 9.14 (5.33–15.7) 0.000 2.21 22 points
 Scar 2.81 (1.32–5.96) 0.007 1.03 10 points 59.4
 No X-ray 0.93 (0.43–2.01) 0.851
 Tuberculin test
 Non-reactor 1.0 0 points
 Reactor 4.03 (1.63–9.98) 0.003 1.39 14 points 6.5
 Not undertaken 2.64 (1.49–4.70) 0.001 0.97 10 points
Related to HIV 42.1
CD4 T cell count
 ≥200 1.0
 <200 3.19 (1.82–5.57) 0.000 1.16 12 points 42.1

*To optimize the rounding off of the score, the regression scores were multiplied by 10.

**For people living with HIV and suspected smear-negative pulmonary TB, whose criteria on entering the study was weight loss.

*** Population diagnosis attributed percent - percent of diagnosis attributed to a factor or group of factors.

Sample size 1276 individuals.