Table 2. Multivariate analysis of the factors associated to the diagnosis of pulmonary TB, and the scoring for each variable, in HIV-infected adults and suspected smear-negative pulmonary TB, in Pernambuco, Brazil, 2007–2010.
Variables | OR (95%-CI) | p-value | β | New score* | % PDA%*** |
Model | 68.2 | ||||
Clinical Symptoms | 88.4 | ||||
Cough** | |||||
No | 1.0 | – | 0 points | ||
Yes | 3.96 (1.95–8.05) | 0.000 | 1.38 | 14 points | 66.0 |
Weight loss | |||||
No | 1.0 | – | 0 points | ||
Yes | 2.44 (1.43–4.15) | 0.001 | 0.89 | 9 points | 43.9 |
Fever | |||||
No | 1.0 | – | 0 points | ||
Yes | 1.99 (1.22–3.23) | 0.005 | 0.69 | 7 points | 25.3 |
Malnutrition | |||||
No | 1.0 | – | 0 points | ||
Yes | 2.62 (1.51–4.54) | 0.001 | 0.96 | 10 points | 18.6 |
Related to diagnostic methods for TB | 62.0 | ||||
Radiological pattern | |||||
Normal | 1.0 | – | – | 0 points | |
Typical/Atypical | 9.14 (5.33–15.7) | 0.000 | 2.21 | 22 points | |
Scar | 2.81 (1.32–5.96) | 0.007 | 1.03 | 10 points | 59.4 |
No X-ray | 0.93 (0.43–2.01) | 0.851 | – | ||
Tuberculin test | |||||
Non-reactor | 1.0 | – | – | 0 points | |
Reactor | 4.03 (1.63–9.98) | 0.003 | 1.39 | 14 points | 6.5 |
Not undertaken | 2.64 (1.49–4.70) | 0.001 | 0.97 | 10 points | |
Related to HIV | 42.1 | ||||
CD4 T cell count | |||||
≥200 | 1.0 | – | – | ||
<200 | 3.19 (1.82–5.57) | 0.000† | 1.16 | 12 points | 42.1 |
*To optimize the rounding off of the score, the regression scores were multiplied by 10.
**For people living with HIV and suspected smear-negative pulmonary TB, whose criteria on entering the study was weight loss.
*** Population diagnosis attributed percent - percent of diagnosis attributed to a factor or group of factors.
Sample size 1276 individuals.