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. 2014 Apr 22;9(4):e96091. doi: 10.1371/journal.pone.0096091

Figure 6. Effect of sesamin on OVA-induced airway mucus.

Figure 6

(A) Representative lung tissue sections stained with PAS frommice of sham group, OVA-sensitized and challenged mice treated with vehicle, or sesamin (1, 10, or 20 mg/kg b.w.,i.p.). (B) The number of goblet cells was dramatically increased in mice receiving OVA-sensitization and challenge compared with mice receiving sham treatment (n = 11 and 8). In OVA-sensitized and challenged animals, number of goblet cells was significantly reduced in mice treated with 10 or 20 (n = 11 and 7, respectively) but not with 1 mg/kg sesamin (n = 8), compared with mice treated with vehicles. (C) Mucus occlusion was significantly attenuated in OVA-sensitized and challenged mice with 10 or 20 mg/kg sesamin (n = 13 and 7) but not with 1 mg/kg sesamin treatments (n = 10), compared with mice treated with vehicles (n = 9). Each bar represents the mean ± S.E.M. (D) MUC5AC mRNA levels were upregulated in lungs of OVA-sensitized and challenged mice and were suppressed by sesamin. (E) Relative levels of MUC5AC were normalized to its own GAPDH internal control and were quantified from 3 experiments. Statistical significance was defined as ### p<0.01 compared with the sham group; and * p<0.05, ** p<0.01, *** p<0.001 compared with the OVA+vehicle group.