Table 4.
Estrogen receptor (ER) and progesterone receptor (PR) status of breast tumor and PA level at age 14, age 30 and at enrollment among 1,767 breast cancer cases in the Norwegian Women and Cancer Study
| |
PA Level |
||||||
|---|---|---|---|---|---|---|---|
| ER/PR status | N cases | Very low | Low | Moderate | High | Very high | P trend |
|
ER+/PR+
a
|
872 |
56 |
188 |
373 |
208 |
47 |
|
| PA at enrollment |
|
1.07 (0.81, 1.42) |
0.94 (0.79, 1.12) |
1.0 ref |
0.95 (0.80, 1.12) |
0.87 0(.65, 1.19) |
0.49 |
| PA at age 14 |
|
0.68 (0.40, 1.16) |
0.74 (0.58, 0.95) |
1.0 ref |
1.02 (0.87, 1.20) |
1.03 (0.85, 1.25) |
0.02 |
| PA at age 30 |
|
1.53 (1.00, 2.36) |
1.10 (0.89, 1.40) |
1.0 ref |
0.95 (0.81, 1.12) |
0.90 (0.71, 1.13) |
0.04 |
|
ER+/PR-
a
|
294 |
17 |
73 |
100 |
84 |
20 |
|
| PA at enrollment |
|
1.32 (0.78, 2.22) |
1.43 (1.06, 1.94) |
1.0 ref |
1.40 (1.04, 1.87) |
1.32 (0.81, 2.13) |
0.98 |
| PA at age 14 |
|
0.83 (0.36, 1.88) |
0.62 (0.40, 0.98) |
1.0 ref |
0.92 (0.70, 1.22) |
1.28 (0.93, 1.76) |
0.02 |
| PA at age 30 |
|
1.21 (0.53, 2.75) |
0.84 (0.57, 1.26) |
1.0 ref |
1.00 (0.76, 1.30) |
1.03 (0.70, 1.51) |
0.68 |
|
ER-/PR-
a
|
206 |
8 |
47 |
91 |
52 |
8 |
|
| PA at enrollment |
|
0.70 (0.34, 1.46) |
1.03 (0.72, 1.47) |
1.0 ref |
0.94 (0.67, 1.32) |
0.57 (0.28, 1.18) |
0.51 |
| PA at age 14 |
|
1.60 (0.73, 3.49) |
1.06 (0.67, 1.70) |
1.0 ref |
1.10 (0.78, 1.54) |
1.15 (0.76, 1.74) |
0.94 |
| PA at age 30 | 0.56 (0.14, 2.28) | 0.78 (0.48, 1.27) | 1.0 ref | 0.90 (0.66, 1.24) | 0.81 (0.50, 1.30) | 0.97 | |
aMultivariable model with relative risks and 95% confidence intervals used the attained age as the underlying time variable. Covariates adjusted for in the model were height, body mass index, smoking status, smoking duration (pack years), age at menarche, use of oral contraceptives, age at first birth, parity, use of hormone replacement therapy, self-reported disease and history of breast cancer in the participant’s mother.