Table 2.
The diagnostic accuracy of CSF lactate for bacterial meningitis by cutoff point
| CSF lactate (mmol/l) |
n = 451 |
Sensitivity |
Specificity |
Negative predictive value (NPV) |
|---|---|---|---|---|
| n (%) | n ( %) (95% CI) | n (%) (95% CI) | n % (95% CI) | |
| ≥1.0 mmol/l |
442 (98) |
100 (91.2-100) |
2.8 (1.3-5.2) |
100 (66.4-100) |
| ≥1.5 mmol/l |
388 (86) |
100 (91.2-100) |
25.2 (20.5-30.2) |
100 (95.6-100) |
| ≥2.0 mmol/l |
246 (55) |
97.5 (86.8-99.9) |
55.2 (49.6-60.7) |
99.4 (97.0-100) |
| ≥2.5 mmol/l |
102 (23) |
95.0 (83.1-99.4) |
85.6 (81.3-89.2) |
99.3 (97.5-99.9) |
| ≥3.0 mmol/l |
56 (12) |
95.0 (83.1-99.4) |
93.6 (90.3-96.0) |
99.3 (97.7-99.9) |
| ≥3.5 mmol/l |
47 (10) |
90.0 (76.3-97.2) |
96 (93.3-97.9) |
98.7 (96.8-99.7) |
| ≥4.0 mmol/l |
34 (7.5) |
82.5 (67.2-92.7) |
96.3 (93.7-98.1) |
97.8 (95.6-99.1) |
| ≥4.5 mmol/l |
30 (6.6) |
72.5 (56.1-85.4) |
96.6 (94.0-98.3) |
96.6 (94.0-98.3) |
| ≥5.0 mmol/l | 26 (5.8) | 72.5 (56.1-85.4) | 97.5 (95.2-98.9) | 96.2 (94.1-98.3) |