Table 1.
Patient characteristics and their variables as predictors for disease-spesific survival in 335 NSCLC patients (univariate analyses; log-rank test)
|
Characteristics |
Patients |
Median survival |
5-year survival |
P |
|
|---|---|---|---|---|---|
| n | (%) | months | % | ||
|
Age |
|
|
|
|
|
| ≤ 65 years |
156 |
(47) |
98 |
55 |
0.42 |
| >65 years |
179 |
(53) |
NR |
60 |
|
|
Sex |
|
|
|
|
|
| Female |
82 |
(24) |
190 |
64 |
0.22 |
| Male |
253 |
(76) |
98 |
56 |
|
|
Smoking |
|
|
|
|
|
| Never |
15 |
(5) |
19 |
43 |
0.26 |
| Current |
215 |
(64) |
NR |
60 |
|
| Former |
105 |
(31) |
84 |
55 |
|
|
Performance status |
|
|
|
|
|
| PS 0 |
197 |
(59) |
NR |
63 |
0.016 |
| PS 1 |
120 |
(36) |
64 |
52 |
|
| PS 2 |
18 |
(5) |
25 |
33 |
|
|
Weight loss |
|
|
|
|
|
| < 10% |
303 |
(90) |
190 |
58 |
0.76 |
| > 10% |
32 |
(10) |
98 |
57 |
|
|
Histology |
|
|
|
|
|
| SCC |
191 |
(57) |
NR |
66 |
0.028 |
| Adenocarcinoma |
113 |
(34) |
54 |
46 |
|
| LCC |
31 |
(9) |
98 |
56 |
|
|
Differentiation |
|
|
|
|
|
| Poor |
138 |
(41) |
47 |
47 |
< 0.001 |
| Moderate |
144 |
(43) |
190 |
65 |
|
| Well |
53 |
(16) |
NR |
68 |
|
|
Surgical procedure |
|
|
|
|
|
| Lobectomy + wedge* |
243 |
(73) |
190 |
62 |
0.007 |
| Pneumonectomy |
92 |
(27) |
37 |
47 |
|
|
Pathological stage |
|
|
|
|
|
| I |
157 |
(47) |
NR |
61 |
< 0.001 |
| II |
136 |
(40) |
62 |
51 |
|
| IIIa |
42 |
(13) |
17 |
23 |
|
|
Tumor status |
|
|
|
|
|
| 1 |
85 |
(25) |
190 |
75 |
< 0.001 |
| 2 |
188 |
(56) |
84 |
57 |
|
| 3 |
62 |
(19) |
25 |
36 |
|
|
Nodal status |
|
|
|
|
|
| 0 |
232 |
(69) |
NR |
67 |
< 0.001 |
| 1 |
76 |
(23) |
35 |
43 |
|
| 2 |
27 |
(8) |
18 |
18 |
|
|
Surgical margins |
|
|
|
|
|
| Free |
307 |
(92) |
190 |
59 |
0.37 |
| Not free |
28 |
(8) |
47 |
48 |
|
|
Vascular infiltration |
|
|
|
|
|
| No |
284 |
(85) |
190 |
62 |
0.001 |
| Yes | 51 | (15) | 27 | 33 | |
Statistically significant results in bold font.
*Wedge, n = 10.
Abbreviations:NR not reached, PS performance status, SCC squamos cell carcinoma, LCC large-cell carcinoma. Adenocarcinoma including cases with bronchioloalveolar carcinoma.