Table 2.
miR-182 in tumor cells and stroma as predictors for disease-specific survival in NSCLC patients (univariate analysis; log-rank test) and results of Cox regression analysis summarizing significant independent prognostic factors
| Characteristics | Pts (n) | Pts (%) | Median survival (months) | 5-year survival (%) | Univariate (P) | Multi-variate (P) | HR (95% CI) |
|---|---|---|---|---|---|---|---|
|
Total (n = 335) |
|
|
|
|
0.062 |
0.098 |
0.73 |
| Low |
190 |
57 |
98 |
55 |
|
|
(0.50-1.06) |
| High |
115 |
34 |
NR |
62 |
|
|
|
| Missing |
30 |
9 |
|
|
|
|
|
|
Pathological stage |
|
|
|
|
|
|
|
|
Stage I (n = 143) |
|
|
|
|
0.97 |
NE |
NE |
| Low |
87 |
61 |
190 |
73 |
|
|
|
| High |
56 |
39 |
NR |
73 |
|
|
|
|
Stage II (n = 127) |
|
|
|
|
0.003 |
0.020 |
0.50 |
| Low |
80 |
63 |
33 |
39 |
|
|
0.28-0.90 |
| High |
47 |
37 |
NR |
63 |
|
|
|
|
Stage III (n = 35) |
|
|
|
|
0.69 |
NE |
NE |
| Low |
23 |
66 |
23 |
39 |
|
|
|
| High |
12 |
34 |
15 |
17 |
|
||
|
Histology |
|
|
|
|
|
|
|
| SCC (n = 172) |
|
|
|
|
0.042 |
0.048 |
0.57 |
| Low |
104 |
60 |
NR |
58 |
|
|
0.33-0.99 |
| High |
68 |
40 |
NR |
74 |
|
|
|
|
AC (n = 106) |
|
|
|
|
0.316 |
NE |
NE |
| Low |
69 |
65 |
47 |
45 |
|
|
|
| High |
37 |
35 |
57 |
50 |
|
|
|
|
LCC (n = 27) |
|
|
|
|
0.285 |
NE |
NE |
| Low |
17 |
63 |
NR |
80 |
|
|
|
| High | 10 | 37 | 58 | 39 |
Statistically significant results in bold font.
Abbreviations:NR not reached, PS performance status, SCC squamous cell carcinoma, AC adenocarcinoma, LCC large-cell carcinoma, NE not entered due to insignificance. Adenocarcinoma including cases with bronchioloalveolar carcinoma.