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. 2014 Feb 14;12:13. doi: 10.1186/1741-7007-12-13

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Copyright © 2014 Chatterjee et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Loss of Pax6 results in precocious formation and expanded expression of Shh in the MDO. (A-H) ISH for Shh and Ptch1 on coronal sections of E12.5 embryos of the indicated genotypes. (I and J) Wholemount ISH for Shh in control (I) and Pax6^Sey/Sey(J) embryos at E9.5. Arrows denote the MDO; brackets show the expanded domain of Shh in the MDO; dashed line arrow indicates the dorsally (rostrally) and ventrally (caudally) expanded Ptch1 expression domains in F; the red arrowhead in J indicates the precocious induction of the ZLI Shh expression in Pax6^Sey/Sey embryos. Scale bar in (A): 200 μm (A-H). E, embryonic day; ISH, in situ hybridization; MDO, mid-diencephalic organizer; ZLI, zona limitans intrathalamica.