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CLR01 inhibits transthyretin (TTR) aggregation in a cell culture system. (A) Immunodetection of TTR oligomers in a dot-blot filtration assay of conditioned medium from TTR L55P-transfected Schwannoma RN22 cells grown in the absence (control) or in the presence of CLR01 or epigallocatechin gallate (EGCG). (B) Densitometric analysis of the dot-blot assay showing the percentage of inhibition of aggregate formation by each compound, compared with the control (0 % inhibition) (***p < 0.005)
