Table 1.
Grade | Degree of the proximal convoluted tubule necrosis |
---|---|
0 |
Normal histology |
1 |
Mitoses and necrosis of individual cells |
2 |
Necrosis of individual cells in adjacent proximal convoluted tubules, with survival of surrounding tubules |
3 |
Necrosis confined to the distal third of the proximal convoluted tubule with a band of necrosis extending across the inner cortex |
4 | Necrosis affecting all three segments of the proximal convoluted tubule |
The numerical scoring system for the histopathological evaluation of renal ischemia was first outlined by Jablonski et al. [22]. Histological assessment of kidney slices stained with hematoxylin-eosin was performed by a pathologist under a light microscope. Grade 0 indicates normal proximal convoluted tubule, Grade 4 indicates severly damaged proximal convoluted tubule.