Table 4.
Univariate analysis of lymph nodes related variables and other clinical factors for 5-year survival
| Variable | Patient no. | LFS (%) | p | NFS (%) | p | LRFS (%) | p | DMFS (%) | p | PFS (%) | p | OS (%) | p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Both CLNs and RLNs |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Yes |
77 |
77.2 |
0.068 |
78.4 |
0.112 |
74.6 |
0.034 |
72.5 |
0.004 |
65.5 |
0.003 |
85.3 |
0.119 |
| No |
65 |
87.1 |
|
87.3 |
|
87.3 |
|
95.2 |
|
87.4 |
|
95.1 |
|
| Size of CLNs |
|
|
|
|
|
|
|
|
|
|
|
|
|
| CLN ≤ 3 cm |
66 |
81.0 |
0.988 |
83.5 |
0.940 |
80.5 |
0.966 |
79.8 |
0.426 |
74.0 |
0.448 |
88.8 |
0.853 |
| CLN 3-6 cm |
44 |
74.1 |
|
74.0 |
|
72.2 |
|
76.0 |
|
64.7 |
|
87.2 |
|
| Number of CLNs |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Single CLN |
62 |
73.9 |
0.328 |
74.1 |
0.174 |
70.7 |
0.154 |
71.5 |
0.240 |
60.3 |
0.132 |
85.6 |
0.562 |
| Multiple CLNs |
48 |
84.8 |
|
86.4 |
|
84.8 |
|
86.7 |
|
81.2 |
|
90.5 |
|
| Age |
|
|
|
|
|
|
|
|
|
|
|
|
|
| <50 |
74 |
83.8 |
0.858 |
84.8 |
0.683 |
82.4 |
0.881 |
81.3 |
0.649 |
77.4 |
0.802 |
89.9 |
0.542 |
| >50 |
68 |
81.0 |
|
81.3 |
|
79.8 |
|
83.0 |
|
74.0 |
|
88.9 |
|
| Sex |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Male |
106 |
79.5 |
0.215 |
80.6 |
0.215 |
78.9 |
0.355 |
77.0 |
0.066 |
70.6 |
0.114 |
86.9 |
0.123 |
| Female |
36 |
89.3 |
|
89.0 |
|
86.3 |
|
94.3 |
|
86.3 |
|
97.1 |
|
| Radiotherapy |
|
|
|
|
|
|
|
|
|
|
|
|
|
| 2D-RT |
35 |
77.5 |
0.263 |
80.5 |
0.526 |
75.2 |
0.207 |
66.7 |
0.009 |
62.4 |
0.027 |
83.0 |
0.160 |
| IMRT |
107 |
83.2 |
|
83.0 |
|
82.1 |
|
89.5 |
|
80.5 |
|
92.7 |
|
| Chemotherapy |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Yes |
16 |
92.3 |
0.379 |
84.6 |
0.995 |
84.6 |
0.815 |
85.7 |
0.937 |
77.9 |
0.950 |
92.3 |
0.765 |
| No |
126 |
80.7 |
|
82.4 |
|
80.2 |
|
81.5 |
|
74.4 |
|
89.4 |
|
| Pathology |
|
|
|
|
|
|
|
|
|
|
|
|
|
| WHO II |
37 |
76.2 |
0.238 |
75.1 |
0.167 |
73.0 |
0.171 |
79.3 |
0.347 |
68.7 |
0.183 |
88.1 |
0.473 |
| WHO III |
105 |
84.3 |
|
85.5 |
|
83.5 |
|
82.6 |
|
76.9 |
|
90.4 |
|
| T Stage |
|
|
|
|
|
|
|
|
|
|
|
|
|
| T1-T2 |
85 |
89.6 |
0.032 |
88.5 |
0.165 |
87.3 |
0.097 |
87.8 |
0.005 |
81.6 |
0.012 |
94.7 |
0.048 |
| T3-T4 | 57 | 72.5 | 75.7 | 72.6 | 72.5 | 65.4 | 82.4 |
Bold numbers, indicated there was statistically significant difference (p value < 0.05).
RLN indicates retropharyngeal lymph node.
CLN indicates cervical lymph node.
2D-RT indicates Conventional two-dimensional radiotherapy and IMRT indicates Intensity-Modulated Radiation Therapy.
LFS, NFS, LRFS, DMFS, PFS and OS indicate for local recurrence-free survival, nodal recurrence-free survival, local-regional recurrence-free survival, distant metastasis-free survival, progression-free survival and overall survival.