Figure 2.

Thresholds for behavioral signs and first EEG seizure during slow intravenous infusion of ATPA. ATPA (25 mm) was infused at a rate of 0.031 ml/min through the lateral tail vein of wild-type, GluK1^−/−, and GluK2^−/− mice. Bars indicate mean ± SEM threshold for induction of behavioral arrest (inactivity), forelimb extension (often accompanied by backward movement), myoclonus, and the first EEG seizure recorded in the hippocampus or BLA. Each bar represents 8–10 mice. Forelimb extension did not occur in any of the 10 GluK1^−/− mice tested and in only 1 of 8 GluK2^−/− mice; the bar represents the value for this animal. **p < 0.01 with respect to wild-type. ***p < 0.001 with respect to wild-type. †No threshold reached at maximum dose.