Figure 7.

CaMKIIαNampt^−/− mice show impairments in hippocampal-dependent learning and memory, but not LTP, at 2–3 months of age. A–F, Evaluation of CaMKIIαNampt^−/− mice (n = 15) and control mice (n = 16) on the MWM. During both the cued (A) and place (C) conditions of the MWM, CaMKIIαNampt^−/− mice exhibited significantly longer path lengths to find the platform relative to control mice. The swimming speed of CaMKIIαNampt^−/− mice was significantly lower than control mice in during acquisition of the cued (B) and the place (D) conditions of the MWM. During the probe condition of the MWM, CaMKIIαNampt^−/− mice exhibited significantly fewer platform crossings (E) and less time (F) in the target quadrant relative to control mice. G, CaMKIIαNampt^−/− mice (n = 7) and control mice (n = 6) exhibit similar LTP at P60. H, Representative fEPSP traces for CaMKIIαNampt^−/− mice (top) and control mice (bottom). Calibration: 1 mV, 5 ms. Data are presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.