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. 2014 Apr 23;34(17):6057–6064. doi: 10.1523/JNEUROSCI.4980-13.2014

Figure 4.

Figure 4.

IL-mPFC BDNF and GluN2B-containing NMDARs mediate consolidation of extinction of a cocaine-CPP. A, Coronal drawings (bregma, +3.72 mm) showing injector tip placements for vehicle (n = 8) and BDNF (n = 8) IL-mPFC infusions. B, IL-mPFC infusions (arrows) of BDNF before the first CPP extinction trial enhanced extinction of the CPP. C, Coronal drawings (bregma, +3.72 mm) showing injector tip placements for vehicle (n = 11) and ifenprodil (n = 12) IL-mPFC infusions. D, IL-mPFC infusions (arrows) of ifenprodil immediately after each CPP extinction trial prevented extinction of the CPP; ***p < 0.001, **p < 0.01, *p < 0.05. Error bars indicate SEM.