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. 2014 Apr 23;34(17):6057–6064. doi: 10.1523/JNEUROSCI.4980-13.2014

Figure 5.

Figure 5.

Extinction of a cocaine-CPP requires and is enhanced by TrkB receptor activation of GluN2B-containing NMDA receptors. A, Coronal drawings (bregma, +3.72 mm) showing injector tip placements for IL-mPFC infusions. B, IL-mPFC infusions (arrows) of ANA-12 (n = 8), but not vehicle (n = 11), before the first CPP trial prevented extinction of the CPP. C, Systemic injections (black arrows) of 7,8DHF (n = 21) before the first CPP trial enhanced extinction compared with vehicle (n = 9), an effect blocked by IL-mPFC infusions (gray arrows) of ifenprodil (n = 10) immediately after the first CPP trial; ***p < 0.001, **p < 0.01. Error bars indicate SEM.