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. 2014 Apr 2;2014:353614. doi: 10.1155/2014/353614

Figure 1.

Figure 1

ASO-mediated lowering of CRP in rats subjected to LADCA ligation. (a) Serum CRP values determined by ELISA for rats injected i.p. with a CRP targeting ASO (ISIS 197178; 150 mg/kg/wk, n = 19) (■), a control ASO (ISIS 141923; 150 mg/kg/wk, n = 9) (□), or an equivalent volume of 0.9% saline (vehicle, n = 8 rats) (○). The arrow indicates the day LADCA ligation surgery was performed. The single asterisks and “ns” above the curves indicate P < 0.0001 or not significant (P > 0.05), respectively, for ANOVAs comparing the three treatment groups on each day. The double asterisks below the lines indicate P < 0.0001 for protected least-squares difference tests comparing the ISIS 197178 treated group to both other groups. (b) Serum IL-6 determined by ELISA for the rats shown in (a). (c) Serum alanine transaminase (ALT) levels determined by ELISA on day 35.