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. 2014 Apr 2;2014:353614. doi: 10.1155/2014/353614

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Copyright © 2014 Alexander J. Szalai et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

ASO-mediated lowering of CRP in rats subjected to coronary artery ligation improves myocardial infarction (MI) induced cardiac dysfunction. LV function was measured by echocardiographic analysis in rats at baseline and at 1 wk after MI. Heart rate (HR), LV end-systolic dimension (LVESD), LV end-diastolic dimension (LVEDD), ejection fraction (EF), fractional shortening (FS), and the mean velocity of circumferential shortening (VCFR) were calculated as described in the Materials and Methods. The results shown are for n = 12 rats treated with ISIS 197178 versus n = 9 controls (see the Results section for details). Single and double asterisks indicate P < 0.05 and P < 0.005 for unpaired t-tests.