Table 2. SI50 values of the FP59 variants. Results were obtained from cytotoxicity assays (n = three independent experiments in triplicates). Errors are the S.E.M.
SI50 (10−13 M) | |||||
---|---|---|---|---|---|
Protein | CHO CL6 | HN6 | RAW | PC-3 | HeLa |
FP59 | 4.0 ± 0.6 | 47.5 ± 5.5 | 10.0 ± 2.9 | 25.4 ± 5.5 | 36.1 ± 5.9 |
FP59rm | 3.8 ± 0.2 | 44.5 ± 3.3 | 5.6 ± 1.3 | 38.9 ± 3.6 | 43.6 ± 13.9 |
FP59AGG | 0.6 ± 0.2* | 5.2 ± 0.5* | 1.3 ± 0.4* | 3.2 ± 0.7* | 3.4 ± 0.7 |
FP59AGGrm | 1.5 ± 0.2 | 16.7 ± 1.3 | 3.0 ± 0.4 | 12.2 ± 2.7 | 14.4 ± 3.3 |
*p values < 0.05 in comparison to FP59 (for FP59rm and for FP59AGG) or FP59AGG (for FP59AGGrm) calculated by one-way ANOVA and Tukey's multiple comparison test.