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Domain structure of the mouse Tet family proteins. Schematic diagrams of predicted conserved domain structures in the three mouse Tet proteins. The conserved domains include CXXC zinc-binding domain, the cysteine-rich domain, and the double-stranded β-helix (DSBH) found in members of the dioxygenase superfamily proteins. Both the Cys-rich and the DSBH domains have been shown to be critical for enzymatic activity. Numbers indicate amino acid numbers.
