Figure 8.

Proteins that bind methyl-CpG. Five members of the MBD protein family are aligned at their MBD domains (purple). Other domains are labeled and include TRD; CXXC domains, which are zinc fingers, some of which are implicated in binding to nonmethylated CpG; GR repeats that may bind; a T:G mismatch glycosylase domain that is involved in repair of 5mC deamination. Kaiso lacks the MBD domain, but binds methylated DNA via zinc fingers (orange) and possesses a POB/BTB domain that is shared with other transcriptional repressors. Domain abbreviations: MBD, methyl-CpG binding domain; TRD, transcriptional repression domain; POZ, poxvirus and zinc finger, a protein–protein interacting domain.